ea0056p650 | Endocrine tumours and neoplasia | ECE2018
Schmohl Kathrin A
, Dohmann Maike
, Schwenk Nathalie
, Bartenstein Peter
, Nelson Peter J
, Spitzweg Christine
Tumour stroma formation is associated with angiogenesis and requires interactions of various different cell types, including endothelial cells and mesenchymal stem cells (MSCs), which are actively recruited into growing tumour stroma. Thyroid hormones T3 and T4 act as non-classical proangiogenic modulators mediated by non-genomic mechanisms via cell surface receptor integrin αvβ3. The deaminated T4 derivative tetrac is a specific inhibitor of thyroid hormone action a...